Look behind the Censorship: Reposting-User Characterization and Muted-Topic Restoration

The emergence of social media has largely eased the way people receive information and participate in public discussions. However, in countries with strict regulations on discussions in the public space, social media is no exception. To limit the degree of dissent or inhibit the spread of "harmful" information, a common approach is to impose information operations such as censorship/suspension on social media. In this paper, we focus on a study of censorship on Weibo, the counterpart of Twitter in China. Specifically, we 1) create a web-scraping pipeline and collect a large dataset solely focus on the reposts from Weibo; 2) discover the characteristics of users whose reposts contain censored information, in terms of gender, device, and account type; and 3) conduct a thematic analysis by extracting and analyzing topic information. Note that although the original posts are no longer visible, we can use comments users wrote when reposting the original post to infer the topic of the original content. We find that such efforts can recover the discussions around social events that triggered massive discussions but were later muted. Further, we show the variations of inferred topics across different user groups and time frames.Comment: Accepted for publication in Proceedings of the International Workshop on Social Sensing (SocialSens 2022): Special Edition on Belief Dynamics, 202

Finite Element Model of X-cor Sandwich Structure

Referring to the mode of Z-pin pre-processing, three kinds of finite element method models including assembled, combined and separated model are introduced. Applicability, advantage and disadvantage of the models are presented, which provide the references for the designers to use finite element method. On the basis of Z-pin bridging law by pullout test and Z-pin pulled out from foam test, separated model of X-cor sandwich structure for finite element analysis is introduced. Double spring coupling elements are introduced to reveal microscopic mechanism of interaction between Z-pin, foam and face-sheets in separated model. The spring parallel to Z-pin interface simulates the relative slip and analyzes the adhesive stress of interface, the spring perpendicular to Z-pin interface simulates the transverse elastic supporting of foam to Z-pin buckling. The finite element simulation on mechanical behavior and interface failure of X-cor sandwich structure are realized

ACY1 Downregulation Enhances the Radiosensitivity of Cetuximab-Resistant Colorectal Cancer by Inactivating the Wnt/β-Catenin Signaling Pathway

Treatment of cetuximab-resistant colorectal cancer (CRC) is a global healthcare problem. This study aimed to assess the effects of radiotherapy on cetuximab-resistant CRC and explore the underlying mechanism. We established a cetuximab-resistant HCT116 cell line (HCT116-R) by extracorporeal shock. Differentially expressed mRNAs were screened from cells treated with different radiation doses using second-generation high-throughput sequencing. Sequence data showed that ACY1 was significantly downregulated in HCT116-R cells after irradiation. Analysis of the GEO and TCGA datasets revealed that high ACY1 expression was associated with lymph node metastasis and a poor prognosis in CRC patients. In addition, immunohistochemistry results from CRC patients revealed that ACY1 protein expression was related to cetuximab resistance and lymph node metastasis. These findings suggested that ACY1 may function as an oncogene to promote CRC progression and regulate the radiosensitivity of cetuximab-resistant CRC. As expected, ACY1 silencing weakened the proliferation, migration, and invasion abilities of HCT116-R cells after radiotherapy. Mechanistically, TCGA data demonstrated that ACY1 expression was closely related to the Wnt/β-catenin pathway in CRC. We validated that radiotherapy first reduced β-catenin levels, followed by decreased expression of the metastasis-related protein E-cadherin. Silencing ACY1 dramatically enhanced these changes in β-catenin and E-cadherin after radiotherapy. In conclusion, ACY1 downregulation could enhance the radiosensitivity of cetuximab-resistant CRC by inactivating Wnt/β-catenin signaling, implying that ACY1 may serve as a radiotherapy target for cetuximab-resistant CRC

Hidden spin polarization in the centrosymmetric Mo S2 crystal revealed via elliptically polarized terahertz emission

The spin polarization in centrosymmetric molybdenum disulfide (MoS2) bulk crystal is recorded by helicity dependent photocurrent exposed as elliptically polarized terahertz (THz) emission. We assign this observation to hidden spin polarization due to the local Dresselhaus effect induced by the molybdenum atomic site asymmetry. This spin polarization induces ultrafast optically controlled circular photogalvanic current that results in elliptically polarized THz emission. Furthermore, this THz radiation exhibits a helicity dependent bleaching effect under opposite circularly polarized excitations due to the spin relaxation. Our results demonstrate the viability of all-optical control of hidden spin polarization in two-dimensional materials and propose the applicability of the THz emission spectroscopy as a sensitive and contactless method to study spintronic physics in two-dimensional materials

sj-docx-1-npx-10.1177_1934578X221124756 - Supplemental material for Active Compounds Screening and Hepatoprotective Mechanism of Shuganning Injection Based on Network Pharmacology and Experimental Validation

Supplemental material, sj-docx-1-npx-10.1177_1934578X221124756 for Active Compounds Screening and Hepatoprotective Mechanism of Shuganning Injection Based on Network Pharmacology and Experimental Validation by Qiyi Wang, Xiaotong Duan, Shan Li, Huaqing Lai, Weina Cheng, Jingwen Ao, Jianyong Zhang and Cancan Duan in Natural Product Communications</p